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EDIBLE

Evaluating Dietary Intervention Before surgicaL treatment for Epilepsy

EDIBLE

Evaluating Dietary Intervention Before surgicaL treatment for Epilepsy
Funding European Union FP7
Portfolio Paediatric, foetal and maternal health
Interventions Other
Randomised Yes
Status Completed
Start Date 01-Sep-2013

The EDIBLE randomised controlled trial was a work package of the European Union FP7 funded project DESIRE (Development and epilepsy - strategies for innovative research to improve diagnosis, prevention and treatment in children with difficult to treat epilepsy).
EDIBLE was open to recruitment across Europe and aimed to identify whether Surgery is more likely to result in seizure freedom if patients with focal cortical dysplasia type II are on the ketogenic diet before Surgery.
Progress with the EDIBLE project opening to recruitment in sites across Europe was challenging due in part to the differing contractual and ethical requirements across sites in different countries. Unfortunately, due to the poor recruitment and lack of remaining time, the study Closed to recruitment in July 2017. A continued study of neuropathology aims to achieve the secondary aims of the study; for instance, whether ketogenic diet leads to methylation changes in tissue.

Publications

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