|Funding||European Union FP7|
|Portfolio||Paediatric, foetal and maternal health|
The EDIBLE randomised controlled trial was a work package of the European Union FP7 funded project DESIRE (Development and epilepsy - strategies for innovative research to improve diagnosis, prevention and treatment in children with difficult to treat epilepsy).
EDIBLE was open to recruitment across Europe and aimed to identify whether Surgery is more likely to result in seizure freedom if patients with focal cortical dysplasia type II are on the ketogenic diet before Surgery.
Progress with the EDIBLE project opening to recruitment in sites across Europe was challenging due in part to the differing contractual and ethical requirements across sites in different countries. Unfortunately, due to the poor recruitment and lack of remaining time, the study Closed to recruitment in July 2017. A continued study of neuropathology aims to achieve the secondary aims of the study; for instance, whether ketogenic diet leads to methylation changes in tissue.