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MINIRES

MINIRES: Minimising the risks of emergence of antibiotic resistance during therapy by precise regimen individualisation and use of combination therapy

MINIRES

MINIRES: Minimising the risks of emergence of antibiotic resistance during therapy by precise regimen individualisation and use of combination therapy
Funding NIHR
Portfolio Clinical Specialties
Interventions Medicine
Randomised Yes
Status Funding awarded/in set-up
Start Date 01-Jan-0001

Resistance to antimicrobial drugs (antibiotics) has been identified in the UK, European Union and many other countries as an important problem which, if not addressed, will have a major effect on how patients will be looked after in the future. One way to address the problem is to make sure that when patients need antibiotics they are given in large enough doses and with other antibiotics to make sure the bacteria being treated do not develop resistance to the antibiotics given. Patients who need to be cared for on Intensive Care Units (ICU) have a greater chance of becoming infected during their hospital stay than patients who spend no time in ICU and chest infections are one of the commonest infections they get. In the last 10 years new knowledge from research in laboratories and patients has made doctors question the way antibiotics are currently given and whether giving two drugs may be better than one. This proposed research will test how best to give antibiotics to inpatients who have chest infections being cared for in ICU. There are several parts to the proposal. First we will assess if measuring antibiotic concentrations in patients and then changing their drug doses to make sure enough drug is given will change the number of patients contracting resistant bacteria or responding to antibiotics. Second, we will test whether two antibiotics, rather than one, will reduce whether bacteria become resistant and/or improve clinical cures. To see if we will need a larger study in the future, we will collect a range of information necessary to plan such a study in a careful and clinically useful way.