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NERVES

Multi-centre randomised control trial comparing the clinical and cost effectiveness of trans-foraminal epidural steroid injection to surgical microdiscectomy for the treatment of acute lumbar radicular pain.(NErve Rootblock VErsus Surgery; NERVES) Resubmitted to HTA 12/201 Management of sciatica (lumbosacral radiculopathy) and suspected sciatica

NERVES

Multi-centre randomised control trial comparing the clinical and cost effectiveness of trans-foraminal epidural steroid injection to surgical microdiscectomy for the treatment of acute lumbar radicular pain.(NErve Rootblock VErsus Surgery; NERVES) Resubmitted to HTA 12/201 Management of sciatica (lumbosacral radiculopathy) and suspected sciatica
Funding NIHR (HTA)
Portfolio Clinical Specialties
Interventions Surgery,Medicine
Randomised Yes
Status Analysis/reporting
Start Date 01-Jul-2014

Two treatments for sciatic leg pain are Surgery or injection but at the moment we don’t know which treatment works best. The aim of this study is to compare the treatments to find out which is most helpful in reducing sciatic leg pain.
This study will treat patients with sciatic leg pain who have suffered a prolapsed (’slipped’) disc. They will receive one of the two treatments that are currently used by the hospitals taking part:
Þ Surgical microdiscectomy
Þ Transforaminal epidural steroid injection (TFESI)

Publications

  • Wilby MJ, Hopkins C, Bedson E, Howlin S, Burnside G, Conroy EJ, Hughes D, Sharma M, Marson A, Clark S, Williamson P. (2018) Nerve root block versus Surgery (NERVES) for the treatment of radicular pain secondary to a prolapsed intervertebral disc herniation: study protocol for a multi-centre randomised controlled trial. Trials 19: 475
    1. https://doi.org/10.1186/s13063-018-2677-5