Meningiomas are a type of brain tumour that start in the linings (membranes) of the brain. Most of these tumours are benign (meaning non-cancerous, grade I) and can be treated with Surgery alone. Very rarely these tumours are malignant (cancerous, grade III) and need treatment with both Surgery and radiotherapy. There is another type of tumour, called atypical meningioma that falls between the benign and malignant group (these are grade II).
Every year in the UK, about 150 patients with atypical meningiomas like yourself have Surgery. After Surgery, there is a chance that atypical meningiomas can grow again and we want to find out what is the most effective treatment for these tumours following Surgery, to reduce the chance of the tumour growing back. So, we are doing a study to find out whether it is more effective to have further treatment after Surgery (radiotherapy) or whether we should monitor patients with regular MRI scans (active monitoring).
So the study is comparing two treatments: Surgery, radiotherapy and active monitoring, or Surgery and active monitoring.
The only way to find out which is the most effective is to do a study to compare these treatment groups. This type of study is called a Randomised Controlled Trial and will help doctors to advise patients about which is the most effective treatment in the future.
- Neuro-Oncology 16(11), 1560–1561, 2014
- Jenkinson, M. D., Javadpour, M., Haylock, B. J., Young, B., Gillard, H., Vinten, J., Bulbeck H., Kumar D., Farrell M., Looby S., Hickey H., Preusser M., Mallucci C. L., Hughes D., Gamble C., Weber, D. C. (2015). The ROAM/EORTC-1308 trial: Radiation versus Observation following surgical resection of Atypical Meningioma: Study protocol for a randomised controlled trial. Trials, 16(1) Trials (2015) 16:519
- Letter to the editor: response to Rogers et al. 2017
- Phase III randomised controlled trials are essential to properly evaluate the role of radiotherapy in WHO grade II meningioma