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Rebel

ReBeL study: a randomized phase I/II trial of lenalidomide and rituximab with or without bendamustine in patients >= 18 years with relapsed follicular lymphoma. A HOVON/GLSG/NCRI study

Rebel

ReBeL study: a randomized phase I/II trial of lenalidomide and rituximab with or without bendamustine in patients >= 18 years with relapsed follicular lymphoma. A HOVON/GLSG/NCRI study
Funding CRUK and HOVON
Portfolio Cancer
Interventions Medicine
Randomised Yes
Status In Follow-up
Start Date 25-Nov-2016

ReBeL is a prospective, randomised, multicentre, international phase II trial (phase I is not being conducted in the UK). ReBeL has two experimental arms; lenalidomide and rituximab versus lenalidomide, rituximab and bendamustine; the most promising of which will be taken on to a large randomised phase III trial. Patients will receive 6 induction cycles of lenalidomide in combination with rituximab with or without bendamustine, followed by 2 years of maintenance treatment rituximab, once every three months. Patients will be followed up every 6 months thereafter, up to 8 years post registration.  

Publications

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