Implant-based breast reconstruction (IBBR) is the most commonly performed reconstructive procedure in the UK. The introduction of techniques to augment the subpectoral pocket has revolutionised the procedure, but there is a lack of high-quality outcome data to describe the safety or effectiveness of these techniques. Randomised controlled trials (RCTs) are the best way of comparing treatments, but surgical RCTs are challenging. The iBRA (implant breast reconstruction evaluation) study aimed to determine the feasibility, design and conduct of a pragmatic RCT to examine the effectiveness of approaches to IBBR. Methods used included a national practice questionnaire to survey current practice and a multi-centre prospective cohort study of patients undergoing IBBR to evaluate the clinical and patient reported outcomes. The preliminary work undertaken within the iBRA study will determine the feasibility, design and conduct of a definitive RCT in IBBR. It will work with the trainee collaborative to build capacity by creating an infrastructure of research-active breast and plastic surgeons which will facilitate future high-quality research that will ultimately improve outcomes for all women seeking reconstructive surgery.
- S Potter, EJ Conroy, RI Cutress, PR Williamson, L Whisker, S Thrush, J Skillman, NLP Barnes. S Mylavaganam, E Teasdale, A Jain, MD Gardiner, JM Blazeby, C Holcombe, on behalf of the Breast Reconstruction Research Collaborative.The iBRA (implant Breast Reconstruction evaluation) study: A multicentre prospective cohort study to evaluate the short-term safety outcomes of immediate implant-based breast reconstruction with and without mesh. Lancet Oncology. (2018)
- S Mylvaganam, E Conroy, PR Williamson, NLP Barnes, RI Cutress, MD Gardiner, A Jain, JM Skilman, S Thrush, LJ Whisker, JM Blazeby, S Potter, C Holcombe, on behalf of the Breast Reconstruction Research Collaborative. Adherence to national best practice guidelines for implant-based breast reconstruction: Results from the iBRA National Practice Questionnaire. European Journal of Surgical Oncology (2018)
- S Mylvaganam, E Conroy, PR Williamson, NLP Barnes, RI Cutress, MD Gardiner, A Jain, JM Skilman, S Thrush, LJ Whisker, JM Blazeby, S Potter, C Holcombe, on behalf of the Breast Reconstruction Research Collaborative.Variation in the provision and practice of implant-based breast reconstruction in the UK: Results from the iBRA national practice questionnaire. Breast (2017)
- S Potter, EJ Conroy, PR Williamson, S Thrush, LJ Whisker, JM Skillman, NLP Barnes, RI Cutress, EM Teasdale, N Mills, S Mylvaganam, OA Branford, K McEvoy, A Jain, MD Gardiner, JM Blazeby, C Holcombe, on behalf of the Breast Reconstruction Research Collaborative. The iBRA (implant Breast Reconstruction evAluation) Study: Protocol for a prospective multicentre cohort study to inform the feasibility, design and conduct of a pragmatic randomised clinical trial comparing new techniques of implant-based breast reconstruction. Pilot and Feasibility Studies (2016)