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    • International Clinical Trials Day - May 20th 2022
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    • LCTC Celebrating Success Event -14th June 2021
    • Breast Cancer Patient share’s experience of clinical research
    • Celebrate International Clinical Trials Day - May 20th 2021
    • Professor Carrol Gamble appointed NIHR Senior Investigator
    • Professor Michael Jenkinson appointed as Sir John Fisher / Royal College of Surgeons of England (RCS) Chair of Surgical Trials in Liverpool
    • Prestigious International Award for LCTC Investigator
    • Torpedo-CF - a major national study in cystic fibrosis - results published
    • ISDR trial results
    • LCTC Chief Investigator, Professor Calum Semple, awarded OBE for COVID-19 efforts
    • LCTC to collaborate on a new NIHR funded neurological trial
    • COVID Cancer Trial
    • COVID-19
    • BASICS study results posted in the Lancet
    • LCTC Launch - 23rd October 2019
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  • Research
    • ACELARATE - A Phase III, open label, multicentre randomised clinical study comparing Acelarin (NUC-1031) with Gemcitabine in patients with metastatic pancreatic carcinoma.
    • ACIT-1 - A Phase I clinical study to determine the optimal dose for the safe immune restoration and immune response of allogeneic cell immunotherapy (ACIT-1) in adult cancer patients.
    • APPA - A Phase I, Partially Blind, Placebo-Controlled, Ascending Single and Multiple Oral Dose, Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study in Healthy Subjects and Osteoarthritis Patients administered APPA-1
    • APRiCOT - A Pilot Randomised Study to Compare Combination Antibiotic Therapy (Ciprofloxacin, Doxycycline and Hydroxychlororquine) with Standard Therapy (Budesonide) in the Treatment of Active Crohn's Disease
    • APTITUDE - A phase II trial of Tocilizumab in anti-TNF refractory patients with JIA associated uveitis
    • ATTAINMENT - A modular, multi-arm, first in human trial to evaluate the safety and tolerability of MDX-124 alone and in combination with anti-cancer treatments, in participants with locally advanced, unresectable or metastatic solid malignancies
    • BASICS - Antibiotic and Silver Impregnated Catheters for ventriculoperitoneal Shunts (BASICS): a multi-centre randomised controlled trial
    • BESS - the use of surfactant for babies with severe bronchiolitis on PICU
    • BIOBehcets - Optimal utilisation of biologic drugs in Behçet’s Disease: a randomised controlled trial of infliximab vs alpha interferon, with genotyping and metabolomic profiling, towards a stratified medicines approach to treatment.
    • BIOPROP20 - Biologically optimised IMRT for Prostate Radiotherapy Hypofractionated radiotherapy with intra-prostatic boosts to tumour nodules in men with intermediate and high risk prostate cancer
    • BOSS - Investigating Slipped Capital Femoral Epiphysis (SCFE) as a childhood precursor to osteoarthritis of the hip in adulthood: A nationwide service evaluation, and nested-cohort study
    • CAPER - A Phase Ib clinical trial of Cyclophosphamide And PEmbrolizumab in metastatic Renal cell carcinoma (CAPER Trial)
    • CASTLE - Randomised factorial design controlled trial comparing carbamazepine, levetiracetam or active monitoring combined with or withou
    • CATCH - A randomised controlled trial comparing the effectiveness of heparin bonded or antibiotic impregnated central venous catheters (CVCs) with standard CVCs for the prevention of hospital acquired blood stream infection in children
    • CCP Cancer-UK - CCP-Cancer UK: Clinical Characterisation Protocol for Severe Emerging Infections in the UK (CCP-UK) – a prospective companion study for patients with Cancer and COVID-19.
    • CCP-UK - ISARIC/WHO Clinical Characterisation Protocol for Severe Emerging Infections in the UK (CCP-UK)
    • CF STORM - A randomised open label trial to assess change in respiratory function for people with cystic fibrosis (pwCF) established on triple combination therapy (Kaftrio™) after rationalisation of nebulised mucoactive therapies (the CF STORM trial)
    • CF-START - The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the
    • CHERRY - CHronic hypERtension and L-citRulline studY (CHERRY)
    • CHOICE - Changing Habits tO Prevent ChIld CariEs (CHOICE): A Randomised Controlled Trial of a Family- Focused Therapeutic Conversation Delivered by Dental Nurses in Primary Care
    • CiPHER - Phase II multicentre study assessing the efficacy of Cabazitaxel in Patients with HER2-negative metastatic breast cancer and having unresectable brain metastases
    • CLL210 - Phase II trial of ofatumumab, dexamethasone and lenalidomide for high-risk CLL (NCRI CLL210)
    • COMICE - A randomised double blind placebo controlled Phase II clinical trial of Cediranib and Olaparib maintenance in advanced recurrent Cervical Cancer (COMICE)
    • COPE - Carboprost vs Oxytocin as the First Line Treatment of Primary Postpartum Haemorrhage. A Phase IV, double-blind, double-dummy, randomized controlled trial.
    • COSTAR - Treating depressive symptomatology in Congolese refugees in Uganda and Rwanda: Culturally adapting and evaluating the efficacy and cost-effectiveness of community-based sociotherapy
    • COVID-LIV - Liverpool Household Covid-19 Cohort Study
    • CRESCENT - Carbogen for Status Epilepticus in Children Trial. Seizure control via pH manipulation: a phase II double blind RCT of inhaled carbogen as adjunctive treatment of paediatric convulsive status epilepticus.
    • DAHANCA-21 - Hyperbaric oxygen treatment of mandibular osteoradionecrosis (DAHANCA 21)
    • D-CODE - Can Vitamin D Supplementation in Patients with Crohn's Disease Improve Symptoms as an Adjunct Therapy: ViDs Feasibility Study
    • DEFeND - Determining the Effectiveness of Fibrin Sealants in Reducing Complications in Patients Undergoing Lateral Neck Dissection: A randomised external pilot trial
    • Dental Recur - Comparison of a new with standard child and family primary care service to reduce the re-occurrence of childhood dental caries (DENTALRECUR Trial)
    • DESTINY - De-Escalation and Stopping Treatment of Imatinib, Nilotinib or sprYcel in chronic myeloid leukaemia (DESTINY)
    • DexEnceph - Dexamethasone in Herpes Simplex Virus Encephalitis
    • DINOSAUR service - Duration of INtravenous antibiOtic therapy for Septic Arthritis or acUte osteomyelitis in a paediatRic population
    • DREAM - Desensitisation Formula REgimens in Milk-Allergic Infants
    • EcLiPSE - Emergency Treatment with Levetiracetam or Phenytoin in Status Epilepticus in Children (EcLiPSE) - A randomised unblinded control
    • EDIBLE - Evaluating Dietary Intervention Before surgicaL treatment for Epilepsy
    • ENCEPH UK - PCS - ENCEPH UK - PCS
    • ENERGIZE - Compensatory changes in energy balance during dapagliflozin treatment in type 2 diabetes
    • ESPAC-3, ESPAC-3(v2) - ADJUVANT CHEMOTHERAPIES IN RESECTABLE PANCREATIC CANCER
    • ESPAC-4 - Combination versus single agent chemotherapy in resectable pancreatic ductal and ampullary cancers.
    • ESPAC-5 - Four arm, prospective, multicentre, randomised, feasibility trial of immediate Surgery compared with neoadjuvant chemotherapies and neoadjuvant chemoradiotherapy.
    • ESPAC-Tplus - CHARACTERISATION OF TUMOUR MOLECULAR RESPONSE PREDICTORS OF CHEMOTHERAPY AND RADIOTHERAPY TREATMENTS FOR PANCREATIC CANCER IN PATIENTS IN THE ESPAC TRIALS.
    • EuroNash - European Audit of Seizure management in Hospitals: EuroNASH
    • EUROPAC2 - Double blind, randomised controlled trial to investigate the efficacy of ANTOX (vers) 1.2 and MGCT (Magnesiocard®) for the treatment of Hereditary Pancreatitis and Idiopathic Chronic Pancreatitis
    • FEMURIII - A definitive randomised controlled trial and economic evaluation of a community-based Rehabilitation package following hip fract
    • Flaviprime - Flavivirus cross-priming potential of live attenuated Japanese encephalitis (JE) vaccine IMOJEV® in flavivirus naïve and flavivirus experienced participants.
    • Foundation - Foundation - Feasibility of conducting a randomised controlled trial to examine the benefit of bilateral cochlear implantation c
    • GASTRIC - A Feasibility Study of routine Gastric residual volume measurement in mechanically ventilated Infants and Children: the GASTRIC
    • GEMCAP - A phase III multicentre randomised clinical trial comparing gemcitabine alone or in combination with capecitabine for the treatment of patients with advanced pancreatic cancer.
    • GOTHIC2 - A 3-arm multi-centre randomised placebo-controlled trial of glycopyrrolate or hyoscine hydrobromide for the treatment of clozapine-induced hypersalivation
    • HAP-FAST - Feasibility study of the clinical and cost-effectiveness of contemporary diagnostics for patients with suspected Hospital-Acquired Pneumonia (HAP).
    • HART-CT - In patients taking Protease Inhibitors does switching to a Bictegravir, Tenofovir Alafenamide and Emtricitabine combination, red
    • HIP - Hartmann’s procedure versus Intersphincteric APE (HiP Study) A Multicentre Prospective Observational Study
    • HipHOp - Feasibility study for a comparative trial of hybrid or cemented implants for total hip replacement. Acronym: HipHOP (Hip arthroplasty with Hybrid Or cemented implants: Patient reported outcomes)
    • HOPON - (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): A Randomised Controlled Trial of Hyperbaric Oxygen to prevent Osteoradionecrosis of the Irradiated Mandible.
    • iBRA - iBRA Study: A National Audit of the Practice and Outcomes of Implant Breast Reconstruction.
    • INCA - Interleukin-1 receptor antagonist treatment for refractory complex regional pain syndrome
    • INPIC - Invasive Procedures In Cancer Pain
    • ISDR - Acceptability and effectiveness of risk based intervals in screening for diabetic retinopathy “towards a personalised approach"
    • ITEM - A PHASE II STUDY OF IMATINIB IN THE TREATMENT OF PATIENTS WITH METASTATIC UVEAL MELANOMA
    • LAP-PIE - Treatment of unresectable Locally Advanced Pancreas (LAP) cancer with Percutaneous Irreversible Electroporation (PIE) following initial systemic chemotherapy: a feasibility randomised controlled trial
    • LION - Pan Tumour Trial of Cox-Inhibitor and Immune Checkpoint Blockade
    • MAGNETIC - MAGnesium NEbuliser Trial In Children (MAGNETIC)
    • MASCOT - Management of Asthma in School age Children On Therapy
    • MINIRES - MINIRES: Minimising the risks of emergence of antibiotic resistance during therapy by precise regimen individualisation and use of combination therapy
    • MYPAN - Open label RCT of MMF versus CYC for the induction of remission of childhood PAN
    • NAMASTE - The Namaste Care intervention to improve the quality of dying for people with advanced dementia living in care homes
    • NASH3 - National Audit of Seizure management in Hospitals - round 3
    • NEO21-RS - NEOTYPE (NEO21-RS): A phase II randomised study of the cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with oestrogen suppression therapy versus oestrogen suppression therapy alone as neoadjuvant therapy in ER-positive intermediate recurrence score primary breast cancer
    • NEOBLADE - Phase II randomised placebo controlled Neoadjuvant chemotherapy study of Nintedanib with Gemcitabine and Cisplatin in locally advanced muscle invasive bladder cancer
    • NERVES - Multi-centre randomised control trial comparing the clinical and cost effectiveness of trans-foraminal epidural steroid injection to surgical microdiscectomy for the treatment of acute lumbar radicular pain.(NErve Rootblock VErsus Surgery; NERVES) Resubmitted to HTA 12/201 Management of sciatica (lumbosacral radiculopathy) and suspected sciatica
    • NICO - CA209-891: Neoadjuvant and adjuvant nivolumab as Immune Checkpoint inhibition in Oral cavity cancer
    • NITRO - NITRO Trial: Neo-adjuvant IntraviTreal Ranibizumab treatment in high risk Ocular melanoma patients: A two stage single centre Phase II single arm study.
    • NOVEMBr - Non-invasive ventilation for the management of children with bronchiolitis: a feasibility study
    • OMNi - The Prospective Ocular Melanoma Natural History Study
    • OVERT - Botulinum toxin-A versus extended release tolterodine in the management of idiopathic overactive bladder in children: A randomised controlled trial
    • PACIFICO - Purine-Alkylator Combination In Follicular lymphoma Immuno-Chemotherapy for Older patients: a phase III comparison of first-line R-CVP versus R-FC lite
    • PANASTA - PANasta Trial Cattell Warren versus Blumgart techniques of pancreatico-jejunostomy following pancreato-duodenectomy – a double blinded multi centred trial
    • PARROT - PARROProphylactic antibiotics to prevent chest infections in children with neurological impairment (PARROT) trialT
    • PEARL - A window of opportunity study to assess the biological effects of progesterone in premenopausal Estrogen Receptor-positive, Progesterone Receptor-positive early breast cancer
    • PETPANC - The impact of combined modality positron emission tomography with computerised tomography scanning (PET/CT) in the diagnosis and management of pancreatic cancer.
    • PETReA - Phase 3 evaluation of PET-guided, Response-Adapted therapy in patients with previously untreated, high tumour burden follicular lymphoma
    • PIROUETTE - A double-blind randomised controlled trial of Pirfenidone in patients with heart failure and preserved ejection fraction
    • PPAC2 - The impact of postoperative Packing of Perianal Abscess Cavities: a multicentre randomised controlled trial
    • Prevail - Preventing Infection using Antibiotic Impregnated Long Lines
    • PROSPER - Feasibility study and pilot trial of an evidence-based low intensity psychosocial intervention delivered by lay therapists for asylum seekers and refugees (PROSPER)
    • PROteKT - Randomised, Controlled, Open-Label Trial Of Rosuvastatin for the Prevention of Aminoglycoside-Induced Kidney Toxicity in CF
    • RAPID-I - Phase IIb, randomised, double-blind, placebo-controlled, mulit-centre trial of infliximab with transcriptomic biomarker and mech
    • RAPTOR - Randomised Controlled Trial of PENTOCLO* in Mandibular Osteoradionecrosis *(Pentoxifylline, Tocopherol & Clodronate)
    • RaTIO - A Phase II randomised study of Durvalumab (MEDI4736) plus Tremelimumab in combination with different radiotherapy modalities for advanced hepatocellular carcinoma
    • REACT - An online randomised controlled trial to evaluate the clinical and cost effectiveness of a peer supported self-management intervention for relatives of people with psychosis or bipolar disorder: Relatives Education And Coping Toolkit
    • REALISTIC - A Phase I, Dose Escalation Trial Of Recombinant Listeria Monocytogenes (Lm)-Based Vaccine Encoding Human Papilloma Virus Serotype 16 Target Antigens (ADXS11-001) In Patients With HPV-16 +ve Oropharyngeal Carcinoma
    • RESILIENT - RandomisEd, controlled, double blind Study to assess mechanistic effects of combination therapy of dapagliflozin with Exenatide QW versus dapagliflozin alone in obese (BMI>30 kg/m2) patients with Type 2 diabetes mellitus.
    • RETURN - InteRventions to rEduce inequaliTies in the Uptake of Routine deNtal care
    • RIAltO - A Randomised Investigation of Alternative Ofatumumab-containing regimens in less fit patients with CLL
    • ROAM - Radiation versus Observation following surgical resection of Atypical Meningioma: a randomised controlled trial (The ROAM trial)
    • ROMANCE - A randomised, controlled multi-centre trial of 26 weeks of subcutaneous Liraglutide (a GLP1 receptor agonist), with or without continuous positive airway pressure (CPAP), in patients with Type 2 Diabetes Mellitus (T2DM) and Obstructive Sleep Apnoea (OSA)
    • SAFE - Seizure first aid training for epilepsy (pilot)
    • SANAD II - A study of Standard and New Antiepileptic Drugs – SANAD-II
    • SATURN - An exploration of the dynamic interaction between IL-17, IL-17 inhibition with (secukinumab) and neutrophils in psoriatic arthritis in vitro and ex vivo with exploratory study on the potential role of Vitamin D
    • SAVER - Sodium Valproate for the Epigenetic Reprogramming of High-Risk Oral Epithelial Dysplasia
    • SCIPI - Subcutaneous Insulin: Pumps or Injections (SCIPI): A randomised controlled trial of continuous subcutaneous insulin infusion(CSII) compared to multiple daily injection(MDI) regimens on insulin in children and young people at diagnosis of type I diabetes mellitus (TIDM).
    • SelPac - A Randomised three-arm, open label, Phase II study of continuous Selumetinib versus continuous or interrupted Selumetinib in combination with weekly Paclitaxel in Metastatic Uveal Melanoma
    • SIR-JIA - Steroid Induction regimen for Juvenile Idiopathic Arthritis
    • SLEEPS - SLEEPS: Safety profiLe, Efficacy and Equivalence in Paediatric intensive care Sedation
    • SUAVE - A RANDOMISED PHASE II STUDY OF SUNITINIB VERSUS DACARBAZINE IN THE TREATMENT OF PATIENTS WITH METASTATIC UVEAL MELANOMA
    • SYCAMORE - Randomised controlled trial of the clinical effectiveness, SafetY and Cost effectiveness of Adalimumab in combination with MethOtRExate for the treatment of juvenile idiopathic arthritis associated uveitis
    • TACE-3 - A two-arm multi-stage (TAMS) seamless phase II/III randomised trial of nivolumab in combination with TACE for patients with intermediate stage HCC
    • TAILoR - TAILoR (TelmisArtan and InsuLin Resistance in HIV): A Dose-Ranging Phase II Randomised Open-Labelled Trial of Telmisartan as a Strategy for the Reduction of Insulin Resistance in HIV-Positive Individuals on Combination Antiretroviral Therapy
    • TeloVac - A prospective, phase III, controlled, multicentre, randomised clinical trial comparing combination Gemcitabine and Capecitabine therapy with concurrent and sequential chemoimmunotherapy using a telomerase vaccine in locally advanced and metastatic pancreatic cancer
    • TIP - Thrombin Inhibition Preoperatively in Early Breast Cancer
    • TITAN - Trial of Induction TPF Therapy in Advanced Head & Neck Cancer.
    • TOPS - Timing Of Primary Surgery for Cleft Palate
    • TORPEDO-CF - Trial of Optimal Therapy for Pseudomonas Eradication in Cystic Fibrosis
    • TREAT - A Randomised Controlled Trial Assessing the Effectiveness, Safety and Cost-effectiveness of Methotrexate versus Ciclosporin in C
    • UK Meningitis - A new diagnostic approach – evaluation of the TRIM test
    • UK-COMPASS - A Risk-adjusted and Anatomically Stratified Cohort Comparison Study of Open Surgery, Endovascular Techniques and Medical Management for Juxtarenal Aortic Aneurysms: The UK COMplex AneurySm Study
    • UK-EDI - UK Early Detection Initiative for Pancreatic Cancer
    • UKLS - UK Lung Screening Trial
    • VIP - A prospective, phase II, double blinded, multicentre, randomised clinical trial comparing combination gemcitabine and Vandetanib therapy with gemcitabine therapy alone in locally advanced or metastatic pancreatic carcinoma
    • VISION - Vision impairment in Stroke: Intervention or Not