Professor Carrol Gamble appointed NIHR Senior Investigator
Professor Michael Jenkinson appointed as Sir John Fisher / Royal College of Surgeons of England (RCS) Chair of Surgical Trials in Liverpool
Prestigious International Award for LCTC Investigator
Torpedo-CF - a major national study in cystic fibrosis - results published
ISDR trial results
LCTC Chief Investigator, Professor Calum Semple, awarded OBE for COVID-19 efforts
LCTC to collaborate on a new NIHR funded neurological trial
COVID Cancer Trial
BASICS study results posted in the Lancet
LCTC Launch - 23rd October 2019
5th ICTMC Conference in Brighton
Patient and Public Involvement
ACELARATE - A Phase III, open label, multicentre randomised clinical study comparing Acelarin (NUC-1031) with Gemcitabine in patients with metastatic pancreatic carcinoma.
ACIT-1 - A Phase I clinical study to determine the optimal dose for the safe immune restoration and immune response of allogeneic cell immunotherapy (ACIT-1) in adult cancer patients.
APPA - A Phase I, Partially Blind, Placebo-Controlled, Ascending Single and Multiple Oral Dose, Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study in Healthy Subjects and Osteoarthritis Patients administered APPA-1
APRiCOT - A Pilot Randomised Study to Compare Combination Antibiotic Therapy (Ciprofloxacin, Doxycycline and Hydroxychlororquine) with Standard Therapy (Budesonide) in the Treatment of Active Crohn's Disease
APTITUDE - A phase II trial of Tocilizumab in anti-TNF refractory patients with JIA associated uveitis
BASICS - Antibiotic and Silver Impregnated Catheters for ventriculoperitoneal Shunts (BASICS): a multi-centre randomised controlled trial
BBC-01 - BBC: Phase II study of neoadjuvant cisplatin and gemcitabine chemotherapy versus upfront Surgery in patients with resectable proximal biliary tract cancer
BESS - the use of surfactant for babies with severe bronchiolitis on PICU
BIOBehcets - Optimal utilisation of biologic drugs in Behçet’s Disease: a randomised controlled trial of infliximab vs alpha interferon, with genotyping and metabolomic profiling, towards a stratified medicines approach to treatment.
BIOPROP20 - Biologically optimised IMRT for Prostate Radiotherapy Hypofractionated radiotherapy with intra-prostatic boosts to tumour nodules in men with intermediate and high risk prostate cancer
BOSS - Investigating Slipped Capital Femoral Epiphysis (SCFE) as a childhood precursor to osteoarthritis of the hip in adulthood: A nationwide service evaluation, and nested-cohort study
CAPER - A Phase Ib clinical trial of Cyclophosphamide And PEmbrolizumab in metastatic Renal cell carcinoma (CAPER Trial)
CASTLE - Randomised factorial design controlled trial comparing carbamazepine, levetiracetam or active monitoring combined with or withou
CATCH - A randomised controlled trial comparing the effectiveness of heparin bonded or antibiotic impregnated central venous catheters (CVCs) with standard CVCs for the prevention of hospital acquired blood stream infection in children
CCP Cancer-UK - CCP-Cancer UK: Clinical Characterisation Protocol for Severe Emerging Infections in the UK (CCP-UK) – a prospective companion study for patients with Cancer and COVID-19.
CCP-UK - ISARIC/WHO Clinical Characterisation Protocol for Severe Emerging Infections in the UK (CCP-UK)
CF-START - The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the
CHERRY - CHronic hypERtension and L-citRulline studY (CHERRY)
CiPHER - Phase II multicentre study assessing the efficacy of Cabazitaxel in Patients with HER2-negative metastatic breast cancer and having unresectable brain metastases
CLL210 - Phase II trial of ofatumumab, dexamethasone and lenalidomide for high-risk CLL (NCRI CLL210)
COMICE - A randomised double blind placebo controlled Phase II clinical trial of Cediranib and Olaparib maintenance in advanced recurrent Cervical Cancer (COMICE)
COPE - Carboprost vs Oxytocin as the First Line Treatment of Primary Postpartum Haemorrhage. A Phase IV, double-blind, double-dummy, randomized controlled trial.
COSTAR - Treating depressive symptomatology in Congolese refugees in Uganda and Rwanda: Culturally adapting and evaluating the efficacy and cost-effectiveness of community-based sociotherapy
COVID-LIV - Liverpool Household Covid-19 Cohort Study
CPET-Panc - Exercise Testing In Chemotherapy
DAHANCA-21 - Hyperbaric oxygen treatment of mandibular osteoradionecrosis (DAHANCA 21)
D-CODE - Can Vitamin D Supplementation in Patients with Crohn's Disease Improve Symptoms as an Adjunct Therapy: ViDs Feasibility Study
DEFeND - Determining the Effectiveness of Fibrin Sealants in Reducing Complications in Patients Undergoing Lateral Neck Dissection: A randomised external pilot trial
Dental Recur - Comparison of a new with standard child and family primary care service to reduce the re-occurrence of childhood dental caries (DENTALRECUR Trial)
DESTINY - De-Escalation and Stopping Treatment of Imatinib, Nilotinib or sprYcel in chronic myeloid leukaemia (DESTINY)
DexEnceph - Dexamethasone in Herpes Simplex Virus Encephalitis
DINOSAUR service - Duration of INtravenous antibiOtic therapy for Septic Arthritis or acUte osteomyelitis in a paediatRic population
DREAM - Desensitisation Formula REgimens in Milk-Allergic Infants
EcLiPSE - Emergency Treatment with Levetiracetam or Phenytoin in Status Epilepticus in Children (EcLiPSE) - A randomised unblinded control
EDIBLE - Evaluating Dietary Intervention Before surgicaL treatment for Epilepsy
ENCEPH UK - PCS - ENCEPH UK - PCS
ENERGIZE - Compensatory changes in energy balance during dapagliflozin treatment in type 2 diabetes
ESPAC-3, ESPAC-3(v2) - ADJUVANT CHEMOTHERAPIES IN RESECTABLE PANCREATIC CANCER
ESPAC-4 - Combination versus single agent chemotherapy in resectable pancreatic ductal and ampullary cancers.
ESPAC-5F - Four arm, prospective, multicentre, randomised, feasibility trial of immediate Surgery compared with neoadjuvant chemotherapies and neoadjuvant chemoradiotherapy.
ESPAC-Tplus - CHARACTERISATION OF TUMOUR MOLECULAR RESPONSE PREDICTORS OF CHEMOTHERAPY AND RADIOTHERAPY TREATMENTS FOR PANCREATIC CANCER IN PATIENTS IN THE ESPAC TRIALS.
EuroNash - European Audit of Seizure management in Hospitals: EuroNASH
EUROPAC2 - Double blind, randomised controlled trial to investigate the efficacy of ANTOX (vers) 1.2 and MGCT (Magnesiocard®) for the treatment of Hereditary Pancreatitis and Idiopathic Chronic Pancreatitis
FEMURIII - A definitive randomised controlled trial and economic evaluation of a community-based Rehabilitation package following hip fract
Flaviprime - Flavivirus cross-priming potential of live attenuated Japanese encephalitis (JE) vaccine IMOJEV® in flavivirus naïve and flavivirus experienced participants.
Foundation - Foundation - Feasibility of conducting a randomised controlled trial to examine the benefit of bilateral cochlear implantation c
GASTRIC - A Feasibility Study of routine Gastric residual volume measurement in mechanically ventilated Infants and Children: the GASTRIC
GEMCAP - A phase III multicentre randomised clinical trial comparing gemcitabine alone or in combination with capecitabine for the treatment of patients with advanced pancreatic cancer.
HART-CT - In patients taking Protease Inhibitors does switching to a Bictegravir, Tenofovir Alafenamide and Emtricitabine combination, red
HIP - Hartmann’s procedure versus Intersphincteric APE (HiP Study) A Multicentre Prospective Observational Study
HipHOp - Feasibility study for a comparative trial of hybrid or cemented implants for total hip replacement. Acronym: HipHOP (Hip arthroplasty with Hybrid Or cemented implants: Patient reported outcomes)
HOPON - (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): A Randomised Controlled Trial of Hyperbaric Oxygen to prevent Osteoradionecrosis of the Irradiated Mandible.
iBRA - iBRA Study: A National Audit of the Practice and Outcomes of Implant Breast Reconstruction.
INPIC - Invasive Procedures In Cancer Pain
ISDR - Acceptability and effectiveness of risk based intervals in screening for diabetic retinopathy “towards a personalised approach"
ITEM - A PHASE II STUDY OF IMATINIB IN THE TREATMENT OF PATIENTS WITH METASTATIC UVEAL MELANOMA
LAP-PIE - Treatment of unresectable Locally Advanced Pancreas (LAP) cancer with Percutaneous Irreversible Electroporation (PIE) following initial systemic chemotherapy: a feasibility randomised controlled trial
LCTU Post-Trial Tissue Bank - LCTU Post-Trial Tissue Bank
LECMC Biomarker Discovery Programme - Liverpool Experimental Cancer Medicine Centre (LECMC) Biomarker Discovery Programme and Prospective Sample Collection
MAGNETIC - MAGnesium NEbuliser Trial In Children (MAGNETIC)
MASCOT - Management of Asthma in School age Children On Therapy
MINIRES - MINIRES: Minimising the risks of emergence of antibiotic resistance during therapy by precise regimen individualisation and use of combination therapy
MYPAN - Open label RCT of MMF versus CYC for the induction of remission of childhood PAN
NAMASTE - The Namaste Care intervention to improve the quality of dying for people with advanced dementia living in care homes
NASH3 - National Audit of Seizure management in Hospitals - round 3
NEO21-RS - NEOTYPE (NEO21-RS): A phase II randomised study of the cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with oestrogen suppression therapy versus oestrogen suppression therapy alone as neoadjuvant therapy in ER-positive intermediate recurrence score primary breast cancer
NEOBLADE - Phase II randomised placebo controlled Neoadjuvant chemotherapy study of Nintedanib with Gemcitabine and Cisplatin in locally advanced muscle invasive bladder cancer
NERVES - Multi-centre randomised control trial comparing the clinical and cost effectiveness of trans-foraminal epidural steroid injection to surgical microdiscectomy for the treatment of acute lumbar radicular pain.(NErve Rootblock VErsus Surgery; NERVES) Resubmitted to HTA 12/201 Management of sciatica (lumbosacral radiculopathy) and suspected sciatica
NICO - CA209-891: Neoadjuvant and adjuvant nivolumab as Immune Checkpoint inhibition in Oral cavity cancer
NITRO - NITRO Trial: Neo-adjuvant IntraviTreal Ranibizumab treatment in high risk Ocular melanoma patients: A two stage single centre Phase II single arm study.
NOVEMBr - Non-invasive ventilation for the management of children with bronchiolitis: a feasibility study
ORCHID - Outcome Research in Children’s Hip Disease
OVERT - Botulinum toxin-A versus extended release tolterodine in the management of idiopathic overactive bladder in children: A randomised controlled trial
PACIFICO - Purine-Alkylator Combination In Follicular lymphoma Immuno-Chemotherapy for Older patients: a phase III comparison of first-line R-CVP versus R-FC lite
PANASTA - PANasta Trial Cattell Warren versus Blumgart techniques of pancreatico-jejunostomy following pancreato-duodenectomy – a double blinded multi centred trial
PARROT - PARROProphylactic antibiotics to prevent chest infections in children with neurological impairment (PARROT) trialT
PEARL - A window of opportunity study to assess the biological effects of progesterone in premenopausal Estrogen Receptor-positive, Progesterone Receptor-positive early breast cancer
PETPANC - The impact of combined modality positron emission tomography with computerised tomography scanning (PET/CT) in the diagnosis and management of pancreatic cancer.
PETReA - Phase 3 evaluation of PET-guided, Response-Adapted therapy in patients with previously untreated, high tumour burden follicular lymphoma
PIROUETTE - A randomised, double-blind, placebo-controlled, phase 2 study of the efficacy and safety of PIRfenidOne in patients with heart f
PIVOTAL - Pharmacological Individualisation of VOriconazole Therapy for AntifungaL treatment
PLANES - Placental Growth Factor Led Management of the Small for Gestational Age Fetus: A Feasibility Study
PPAC2 - The impact of postoperative Packing of Perianal Abscess Cavities: a multicentre randomised controlled trial
Prevail - Preventing Infection using Antibiotic Impregnated Long Lines
PROSPER - Feasibility study and pilot trial of an evidence-based low intensity psychosocial intervention delivered by lay therapists for a
PROteKT - Randomised, Controlled, Open-Label Trial Of Rosuvastatin for the Prevention of Aminoglycoside-Induced Kidney Toxicity in CF
RAPID-I - Phase IIb, randomised, double-blind, placebo-controlled, mulit-centre trial of infliximab with transcriptomic biomarker and mech
RaTIO - A Phase II randomised study of Durvalumab (MEDI4736) plus Tremelimumab in combination with different radiotherapy modalities for advanced hepatocellular carcinoma
REACT - An online randomised controlled trial to evaluate the clinical and cost effectiveness of a peer supported self-management intervention for relatives of people with psychosis or bipolar disorder: Relatives Education And Coping Toolkit
REALISTIC - A Phase I, Dose Escalation Trial Of Recombinant Listeria Monocytogenes (Lm)-Based Vaccine Encoding Human Papilloma Virus Serotype 16 Target Antigens (ADXS11-001) In Patients With HPV-16 +ve Oropharyngeal Carcinoma
Rebel - ReBeL study: a randomized phase I/II trial of lenalidomide and rituximab with or without bendamustine in patients >= 18 years with relapsed follicular lymphoma. A HOVON/GLSG/NCRI study
RECAP - Three-arm RandomisEd trial of cervical Cerclage, Arabin pessary, and vaginal Progesterone to prevent spontaneous preterm birth in asymptomatic high-risk
RESILIENT - RandomisEd, controlled, double blind Study to assess mechanistic effects of combination therapy of dapagliflozin with Exenatide QW versus dapagliflozin alone in obese (BMI>30 kg/m2) patients with Type 2 diabetes mellitus.
RETURN - InteRventions to rEduce inequaliTies in the Uptake of Routine deNtal care
RIAltO - A Randomised Investigation of Alternative Ofatumumab-containing regimens in less fit patients with CLL
ROAM - Radiation versus Observation following surgical resection of Atypical Meningioma: a randomised controlled trial (The ROAM trial)
ROMANCE - A randomised, controlled multi-centre trial of 26 weeks of subcutaneous Liraglutide (a GLP1 receptor agonist), with or without continuous positive airway pressure (CPAP), in patients with Type 2 Diabetes Mellitus (T2DM) and Obstructive Sleep Apnoea (OSA)
SAFE - Seizure first aid training for epilepsy (pilot)
SANAD II - A study of Standard and New Antiepileptic Drugs – SANAD-II
SATURN - An exploration of the dynamic interaction between IL-17, IL-17 inhibition with (secukinumab) and neutrophils in psoriatic arthritis in vitro and ex vivo with exploratory study on the potential role of Vitamin D
SAVER - Sodium Valproate for the Epigenetic Reprogramming of High-Risk Oral Epithelial Dysplasia
SCIPI - Subcutaneous Insulin: Pumps or Injections (SCIPI): A randomised controlled trial of continuous subcutaneous insulin infusion(CSII) compared to multiple daily injection(MDI) regimens on insulin in children and young people at diagnosis of type I diabetes mellitus (TIDM).
SelPac - A Randomised three-arm, open label, Phase II study of continuous Selumetinib versus continuous or interrupted Selumetinib in combination with weekly Paclitaxel in Metastatic Uveal Melanoma
SHINE - The Use of Acoustic Transmission to Identify Developmental Hip Dysplasia in Babies
SIR-JIA - Steroid Induction regimen for Juvenile Idiopathic Arthritis
SLEEPS - SLEEPS: Safety profiLe, Efficacy and Equivalence in Paediatric intensive care Sedation
STRIDER - A Randomized Controlled Trial of Sildenafil Therapy In Dismal Prognosis Early-Onset Intrauterine Growth Restriction
STRIDER Follow up - STRIDER UK: Phase II Follow-up
SUAVE - A RANDOMISED PHASE II STUDY OF SUNITINIB VERSUS DACARBAZINE IN THE TREATMENT OF PATIENTS WITH METASTATIC UVEAL MELANOMA
SYCAMORE - Randomised controlled trial of the clinical effectiveness, SafetY and Cost effectiveness of Adalimumab in combination with MethOtRExate for the treatment of juvenile idiopathic arthritis associated uveitis
TACE-3 - A two-arm multi-stage (TAMS) seamless phase II/III randomised trial of nivolumab in combination with TACE for patients with intermediate stage HCC
TAILoR - TAILoR (TelmisArtan and InsuLin Resistance in HIV): A Dose-Ranging Phase II Randomised Open-Labelled Trial of Telmisartan as a Strategy for the Reduction of Insulin Resistance in HIV-Positive Individuals on Combination Antiretroviral Therapy
TeloVac - A prospective, phase III, controlled, multicentre, randomised clinical trial comparing combination Gemcitabine and Capecitabine therapy with concurrent and sequential chemoimmunotherapy using a telomerase vaccine in locally advanced and metastatic pancreatic cancer
TIP - Thrombin Inhibition Preoperatively in Early Breast Cancer
TITAN - Trial of Induction TPF Therapy in Advanced Head & Neck Cancer.
TOPS - Timing Of Primary Surgery for Cleft Palate
TORPEDO-CF - Trial of Optimal Therapy for Pseudomonas Eradication in Cystic Fibrosis
TREAT - A Randomised Controlled Trial Assessing the Effectiveness, Safety and Cost-effectiveness of Methotrexate versus Ciclosporin in C
UK Meningitis - A new diagnostic approach – evaluation of the TRIM test
UK-COMPASS - A Risk-adjusted and Anatomically Stratified Cohort Comparison Study of Open Surgery, Endovascular Techniques and Medical Management for Juxtarenal Aortic Aneurysms: The UK COMplex AneurySm Study
UK-EDI - UK Early Detection Initiative for Pancreatic Cancer
UKLS - UK Lung Screening Trial
VIP - A prospective, phase II, double blinded, multicentre, randomised clinical trial comparing combination gemcitabine and Vandetanib therapy with gemcitabine therapy alone in locally advanced or metastatic pancreatic carcinoma
VISION - Vision impairment in Stroke: Intervention or Not